Well, it'd physically plug in, if it's a 1/4 inch TRS.
The tip will connect and the shield will connect. But whatever signal is carried in the ring, won't mate with anything in the Fender's jack. (there's even a possibility the Fender jack may short that ring portion to ground).
Dunno if there's a ready-made adpator that would combine the tip and ring to a mono tip-only plug.
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