Every amp builder has their own ideas of what sounds best. In my head, the shortest distance between two points (i.e. shortest signal path, meaning the least amount of tubes with the least amount of throwaway gain) sounds best, and that always translates to a lower gain amp. You get to hear the nuances (e.g. wood tones) of the guitar. You can always use a box of some sort for the high-gain effect, and we have PLENTY of good-to-great choices nowadays.
All else being equal, your substitution of lower mu tubes with their lower plate impedance can be used effectively to "open up" the tone somewhat. You can freely experiment here, but the lowest mu tube, the 12AU7, is not USUALLY effective as a 1st stage preamp tube, though it has been used successfully in some designs. Use your ears and fingers as a guide.
All else being equal, your substitution of lower mu tubes with their lower plate impedance can be used effectively to "open up" the tone somewhat. You can freely experiment here, but the lowest mu tube, the 12AU7, is not USUALLY effective as a 1st stage preamp tube, though it has been used successfully in some designs. Use your ears and fingers as a guide.
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