My original 5F2H amp was based around a 10 watt 2x8' amp and a single KT66.
The OT was a Hammond 125ESE... if I were to do it over again I'd try using a Hammond 125GSE and big 6L6GC or 6550.
The big SE OT weber was selling, was a Chinese copy of my Marvel/Mag Comp copy of the... guess what?... the Hammond 125ESE. I didn't care for the Chinese copy of the American made copy of the Canadian made Hammond, and subsequently never built another one using any weber transformers.
Also, I quickly found that unless you had the killer 8" speakers from the West side of Chicago, just about any decent 10" speaker pair sounded better.
Two 8" and a single 10" is something I had not really tried... but I did try four 8"s with limited success, fondly called my Bassboy 10... followed by a superior sound with only the two 10" speakers.
I have also tried those same Eminence neo speakers, that of which you mentioned.... they sounded better with an electric guitar, in a guitar tuned amp and a small boost pedal.
However, all in all, they were actually a decent speaker.
Personally, I think I'd put the two 8" on the bottom and the 10" in the middle above them.
I haven't heard many (maybe none) Weber speakers that won't cone cry, edge yowl or ghost note with a good, hot harp mic and guy who can push hard with closed cupping.