I've used a ton of clean boosts including many that are not necassarily made for that like tube screamers. i never had any problem getting a ton of OD with single coils except that you have to realize you WILL get a ton of noise unless you use noiseless pups. I don't...i deal with the noise because the tone is the best. Plus i have a bucker in all my strat's bridge positions. But i use the singles a lot of the time and as i said i deal with the noise. I also feel like you, that the best OD tone is from the amp, hence the clean boost. Although i must admit some of the more killer OD tones i ever got was with a RAT pedal with a clean boost in front of it into a clean amp !
Anyways, any good amp that has a somewhat hi gain pre like a JCM 800 and a clean boost (i use a tube screamer with dist all the way down and level all the way up) gets me all the drive i could ever use.